Biointerfaces

Surfaces are crucial in biology, and in LSST, we are engaged in research of relevance to implants, to understanding the way in which nature lubricates, and its imitation, as well as with novel approaches to the reduction of biofouling. Many of our approaches involve techniques and approaches that we have developed in other areas of research, including gradients and polymer brushes.

References

external pageImparting Nonfouling Properties to Chemically Distinct Surfaces with a Single Adsorbing Polymer: A Multimodal Binding Approach
Ângela Serrano, Stefan Zürcher, Samuele Tosatti and Nicholas D. Spencer
Macromolecular Rapid Communications; 2016; 37(7) pp 622-629
external pageOrthogonal Morphological Feature-Size and Density Gradients for Exploring Synergistic Effects in Biology
Clément V.M. Cremmel, Christian Zink, Katharina Maniura-Weber, Lucio Isa, and Nicholas D. Spencer
Langmuir; 2015; 31(30) pp 8446-8452
external pageThe role of nanostructures and hydrophilicity in osseointegration: In-vitro protein-adsorption and blood-interaction studies
Brigitte S. Kopf, Sylvie Ruch, Simon Berner, Nicholas D. Spencer, Katharina Maniura-Weber
Journal of Biomedical Materials Research: Part A; 2015; 103(8) pp 2661-2672
external pageDifferential regulation of osteogenic differentiation of stem cells on surface roughness gradients
Faia-Torres A.B., Guimond-Lischer S., Rottmar M., Charnley M., Goren T., Maniura-Weber K., Spencer N.D., Textor M., Reis R.L., Neves N.M.
Biomaterials; 2014; 35(33) pp 9023-9032
external pageNonfouling response of hydrophilic uncharged polymers
Ângela Serrano, Olof Sterner, Sophie Mieszkin, Stefan Zürcher, Samuele Tosatti, Maureen E. Callow, James A. Callow and Nicholas D. Spencer
Advanced Functional Materials; 2013; 23(46) pp 5706 - 5718
external pageOrthogonal nanometer-micrometer roughness gradients probe morphological influences on cell behavior
Christian Zink, Heike Hall, Don M. Brunette and Nicholas D. Spencer
Biomaterials; 2012; 33(32) pp 8055-8061