Main content

Surfaces are crucial in biology, and in LSST, we are engaged in research of relevance to implants, to understanding the way in which nature lubricates, and its imitation, as well as with novel approaches to the reduction of biofouling. Many of our approaches involve techniques and approaches that we have developed in other areas of research, including gradients and polymer brushes.


  1. Imparting Nonfouling Properties to Chemically Distinct Surfaces with a Single Adsorbing Polymer: A Multimodal Binding Approach
    Ângela Serrano, Stefan Zürcher, Samuele Tosatti and Nicholas D. Spencer
    Macromolecular Rapid Communications; 2016; 37(7) pp 622-629
  2. Orthogonal Morphological Feature-Size and Density Gradients for Exploring Synergistic Effects in Biology
    Clément V.M. Cremmel, Christian Zink, Katharina Maniura-Weber, Lucio Isa, and Nicholas D. Spencer
    Langmuir; 2015; 31(30) pp 8446-8452
  3. The role of nanostructures and hydrophilicity in osseointegration: In-vitro protein-adsorption and blood-interaction studies
    Brigitte S. Kopf, Sylvie Ruch, Simon Berner, Nicholas D. Spencer, Katharina Maniura-Weber
    Journal of Biomedical Materials Research: Part A; 2015; 103(8) pp 2661-2672
  4. Differential regulation of osteogenic differentiation of stem cells on surface roughness gradients
    Faia-Torres A.B., Guimond-Lischer S., Rottmar M.,  Charnley M., Goren T.,  Maniura-Weber K., Spencer N.D., Textor M., Reis R.L., Neves N.M.
    Biomaterials; 2014; 35(33) pp 9023-9032
  5. Nonfouling response of hydrophilic uncharged polymers
    Ângela Serrano, Olof Sterner, Sophie Mieszkin, Stefan Zürcher, Samuele Tosatti, Maureen E. Callow, James A. Callow and Nicholas D. Spencer
    Advanced Functional Materials; 2013; 23(46) pp 5706 - 5718
  6. Orthogonal nanometer-micrometer roughness gradients probe morphological influences on cell behavior
    Christian Zink, Heike Hall, Don M. Brunette and Nicholas D. Spencer
    Biomaterials; 2012; 33(32) pp 8055-8061
Page URL:
Fri Jul 28 04:40:58 CEST 2017
© 2017 Eidgenössische Technische Hochschule Zürich